国产又大又硬又粗-国产又大又硬又粗国内精品线在线观看-国产又黄又-国产又黄又潮娇喘视频在线-国产又黄又粗又硬又爽视频-国产又黄又大又粗的视频

• 犬尿氨酸是人體必需氨基酸色色氨酸的代謝產物之一,是一種具有多種特殊生理作用的生物活性分子,犬尿氨酸及其代謝產物與多種神經精神疾病、腎功能衰竭、白內障、各種慢性惡性疾病等密切相關。
• 因此，定量測定機體Kynurenine對相關疾病的診斷治療、療效監測及發病機制等研究具有重要參考價值。
• 慢性腎功能衰竭患者（CRF）患者外周血存在較為嚴重的犬尿氨酸代謝紊亂,且與腎功能水平及CRF的某些臨床癥狀密切相關。（來源：李江.慢性腎功能衰竭患者血清色氨酸和犬尿氨酸檢測及其臨床意義. 《中華醫學會第七次全國檢驗醫學學術會議資料匯編》2008年.）
• 丹娜法伯癌癥研究所腫瘤專家、哈佛醫學院醫學助理教授Giannakis說：“在接受納武利尤單抗治療的大多數患者中，我們發現犬尿氨酸的水平升高。這種物質被認為具有免疫抑制作用。”
• 在黑色素瘤患者中，第4周時，78%的患者色氨酸-犬尿氨酸轉化率增加，26.5%的患者增加比例超過50%。在腎癌患者中，納武利尤單抗的治療效果也與犬尿氨酸增加有關。
• 分析表明，黑色素瘤和腎癌患者在接受納武利尤單抗治療后色氨酸-犬尿氨酸轉化率增加，與較低的生存率有關。具體來說，血液檢測顯示轉換率在50%以上的黑色素瘤患者，中位生存期只有15.7個月，而低于這一比例的患者中位生存期超過39個月。腎癌患者中位生存期分別為16.7個月和31.3個月。

 
參考文獻
1. Cavia-Saiz M, Muniz Rodriguez P, Llorente Ayala B, Garcia-Gonzalez M, Coma-Del Corral MJ, Garcia Giron C. The role of plasma IDO activity as a diagnostic marker of patients with colorectal cancer. Mol Biol Rep. 2014 Apr; 41(4):2275-9.
2. Chuang SC, Fanidi A, Ueland PM et al: Circulating biomarkers of tryptophan and the kynurenine pathway and lung cancer risk. Cancer Epidemiol Biomarkers Prev. 2014 Mar; 23(3):461-8 Manual IDKR Kynurenine high sensitive ELISA 29
3. Creelan BC, Antonia S, Bepler G, Garrett TJ, Simon GR, Soliman HH: Indoleamine 2,3-dioxygenase activity and clinical outcome following induction chemotherapy and concurrent chemoradiation in Stage III nonsmall cell lung cancer. Oncoimmunology. 2013 Mar 1; 2(3):e23428
4. Eussen S J PM, Ueland P M, Vollset S E, Nygard O, Midttun O, Sulo G,Tell GS: Kynurenines as predictors of acute coronary events in the Hordaland Health Study. Int J Cardiol. 2015 Jun 15;189:18-24
5. Gupta NK, Thaker AI, Kanuri N, Riehl TE, Rowley CW, Stenson WF, Ciorba MA: Serum analysis of tryptophan catabolism pathway: correlation with Crohn's disease activity. Inflamm Bowel Dis. 2012 Jul; 18(7):1214-20.
6. Murray C, Griffin EW, O’Loughlin E, Lyons A, Sherwin E, Ahmed S, Stevenson N J, et al. Interdependent and independent roles of type I interferons and IL-6 in innate immune, neuroinflammatory and sickness behaviour responses to systemic poly I:C. Brain, Behavior, and Immunity. 2015, 48: 274-286.
7. Pedersen ER, Svingen GF, Schartum-Hansen H, Ueland PM, Ebbing M, Nordrehaug JE, Igland J, Seifert R, Nilsen RM, Nygard O: Urinary excretion of kynurenine and tryptophan, cardiovascular events, and mortality after elective coronary angiography. Eur Heart J. 2013 Sep; 34(34):2689-96.
8. Ristagno G, Latini R, Vaahersalo J, Masson S, Kurola J, Varpula T, Lucchetti J, Fracasso C, Guiso G, Montanelli A, Barlera S, Gobbi M, Tiainen M, Pettila V, Skrifvars MB; FINNRESUSCI Investigators: Early activation of the kynurenine pathway predicts early death and long-term outcome in patients resuscitated from out-of-hospital cardiac arrest. J Am Heart Assoc. 2014; 3:e001094
9. Sulo G, Vollset SE, Nygard O, Midttun O, Ueland PM, Eussen SJ, Pedersen ER, Tell GS: Neopterin and kynurenine-tryptophan ratio as predictors of coronary events in older adults, the Hordaland Health Study. Int J Cardiol. 2013 Sep 30; 168(2):1435-40
10. Suzuki Y, Suda T, Asada K, Miwa S, Suzuki M, Fujie M, Furuhashi K, Nakamura Y, Inui N, Shirai T, Hayakawa H, Nakamura H, Chida K: Serum Indoleamine 2,3- Dioxygenase Activity Predicts Prognosis of Pulmonary Tuberculosis. Clin Vaccine Immunol. 2012 March; 19(3): 436–442
11. Yan EB, Frugier T, Lim CK, Heng B, Sundaram G, Tan M, Rosenfeld JV, et al. Activation of the kynurenine pathway and increased production of the excitotoxin quinolinic acid following traumatic brain injury in humans. Journal of Neuroinflammation. 2015,12(1), 110.

相關指標推薦

1. 人抗酒石酸酸性磷酸酶5b試劑盒（TRACP 5b）   腎性骨營養不良檢測指標
 

2. 骨堿性磷酸酶檢測試劑盒（酶聯免疫法）         腎病患者骨形成檢測指標

3. FGF23(C端)檢測試劑盒(酶聯免疫法)               磷穩態的調節劑 

4. 人全段甲狀旁腺激素檢測試劑盒（酶聯免疫法）      診斷鈣代謝紊亂的重要輔助工具(PTH維持鈣穩態) 

5. 25-羥基維生素D檢測試劑盒（酶聯免疫法）           檢測體內25（OH）D水平，有效預防維生素D不足或缺乏

6. 1，25雙羥基維生素D檢測試劑盒（酶聯免疫法）   維生素D的生物活性鑒定，適用于腎衰竭、腎移植術后檢測

7.  C4D                                                                                     腎移植后體液排斥反應檢測指標