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n血清中Sema4D和Plexin-B1的下降直接減緩對其信號通路的抑制作用， 進而促進前成骨細胞向成骨細胞轉化，成骨細胞功能增加， 數量增多，骨代謝表現為高骨轉化狀態。

應用領域


 

試劑盒信息

1. Semaphorins command cells to move. Kruger RP et al., Nature Rev Mol Cell Biol, 2005; 6:789-800.

2. The semaphorins. Yazdani U and Terman JR, Genome Biol, 2006; 7(3): 211.

3. Biology and function of neuroimmune semaphorins 4A and 4D. Nkyimbeng-Takwi EH and Chapoval SP, Immunol Res, 2011; 50 (1):10-21.

4. Structural basis of semaphorin-plexin signalling B.J.C. Janssen BJC et al., Nature, 2010; 467:1118-1122.

5. Semaphorins and their receptors in immune cell interactions. Suzuki K et al., Nature Immunology, 2007;9:17-23.

6. Sema4D induces angiogenesis through Met recruitment by Plexin B1. Conrotto P et al., Blood, 2005; 105:4321-4329.

7. Diverse roles for semaphorin-plexin signaling in the immune system. Takamatsu H et al., Trends Immunol, 2012; 33(3):127-135. 

8. Bone cell communication factors and Semaphorins. Negishi-Koga T and Takayanagi H, Bonekey Rep, 2012; 1:183.

9. Suppression of bone formation by osteoclastic expression of semaphorin 4D. Negishi-Koga T et al., Nat Med, 2011; 17(11):1473-1480.

10. Soluble SEMA4D/CD100: A novel immunoregulator in infectious and inflammatory diseases. Maleki KT et al., Clinical Immunology, 2016; 163:52-59.

11. Anabolic bone formation via a site specific bone targeting delivery system by interfering with semaphorin 4D expression. Zhang Y et al., J Bone Miner Res, 2015; 30(2): 286-296.

12. Generation and preclinical characterization of an antibody specific for SEMA4D. Fisher TL et al., Mabs, 2016; 8(1):150-162.

13. Coagulation-induced elevated sSEMA 4D concentrations in human serum versus plasma measured by sandwich ELISA. Laber et al., 2018; submitted.