Prostate cancer metastasis models are suitable for testing the efficacy of drug compounds against several dissemination processes and growth in specific microenvironments. The metastasis models are demanding for the drug candidate, but they have an excellent clinical predictivity. Pharmatest offers intratibial models of prostate cancer bone metastasis, where radiography reveals the progression of the bone metastases. When AR positive LNCaP or VCaP cell lines are used, radiography reveals osteoblastic bone metastases typical for prostate cancer, and progression of the disease can be followed by serum PSA measurements. Histological bone samples can be analyzed for tumor area, trabecular bone area and osteoclast number to reveal detailed information about the test compound's effects on bone metastases.
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