Our proprietary in vitro osteoblast assays have been designed for pharmacodynamic testing of new anabolic agents against osteoporosis before entering animal studies. They involve culturing mesenchymal progenitor cells that are first allowed to differentiate into mature osteoblasts, enabling to study direct effects of drug candidates on osteoblast differentiation. The culture period can then be extended to allow the formed osteoblasts to form bone nodules, enabling to study effects of drug candidates on bone forming activity of mature osteoblasts.
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