Our proprietary in vitro osteoclast assays have been designed for pharmacodynamic testing of new therapeutic agents against osteoporosis and cancer-induced bone disease before entering animal studies. They involve culturing osteoclast precursor cells that are first allowed to differentiate into mature bone-resorbing osteoclasts, enabling to study direct effects of drug candidates on osteoclast formation. The culture period can then be extended to allow the formed mature osteoclasts to resorb bone, enabling to study direct effects of drug candidates on resorption activity of mature osteoclasts.
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