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Unique Features

• Animal Models of Rheumatoid Arthritis and Osteoarthritis
• Easy, non-invasive quantification of cartilage degradation
• Strong association to indexes of joint damage, e.g. cartilage erosion
• Demonstration of Chondroprotective Effect of Drugs
• Rapid response to chondroprotective drugs (within 1-2 weeks)
• Early response in CTX-II is highly correlated to histological endpoints³
• CTX-II can be quantified in relevant cartilage explant culture supernatant human origin and animal models
• CTX-II is elevated in both RA and OA rat models
• CTX-II levels are associated with disease activity in RA and OA, primarily indexes of structural damage²
• Useful for dynamic monitoring of cartilage in multiple species
• A complete assay panel supporting bone and cartilage research